Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
BACKGROUND The purpose of this study was to examine the effects of cyclooxygenase (COX) deficiency on baseline functional characteristics and on recovery of left ventricular developed pressure (LVDP) after 20 minutes of global ischemia and 40 minutes of reperfusion in untreated and preconditioned hearts. METHODS AND RESULTS Compared with hearts from wild-type (WT) and COX-2(-/-) mice, baselin...
متن کاملCardiac-Specific Knockout of NCX1
The excitation–contraction coupling cycle in cardiac muscle is initiated by an influx of Ca through voltage-dependent Ca channels. Ca influx induces a release of Ca from the sarcoplasmic reticulum and myocyte contraction. To maintain Ca homeostasis, Ca entry is balanced by efflux mediated by the sarcolemmal Na -Ca exchanger. In the absence of Na -Ca exchange, it would be expected that cardiac m...
متن کاملThe Mitochondrial ROMK Channel is a Molecular Component of MitoKATP
Authors contributed equally to this work.
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Prevention of ischemia-reperfusion injury (IRI) is a challenge in clinical care of the patients with kidney transplants or acute kidney injury, and understanding of the intrinsic mechanisms of resistance to injury in the kidney will lead to a novel therapy. Clusterin, a secreted glycoprotein, is an antiapoptotic protein in cancer cells. Our study is to investigate the role of clusterin in renal...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2020
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2020.01.010